Facile and Highly Enantioselective Synthesis of Axially Chiral Biaryls by Enzymatic Desymmetrization

Takashi Matsumoto,Tadayoshi Konegawa,Takeshi Nakamura,Keisuke Suzuki

Facile and Highly Enantioselective Synthesis of Axially Chiral Biaryls by Enzymatic Desymmetrization

2002

Takashi Matsumoto
Tadayoshi Konegawa
Takeshi Nakamura
Keisuke Suzuki

The axially chiral biaryls 2 were obtained in high enantioselectivity by desymmetrization of the σ-symmetric biaryl diacetates 1 by lipase-catalyzed hydrolysis.

Keywords:

Enantioselective synthesis
Enzyme
Photochemistry
Axial symmetry
Desymmetrization
Hydrolysis
Stereochemistry
Chirality (chemistry)
Axial chirality
Chemistry
Organic chemistry

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