A mixed-ligand Zn(II)-MOF: sensitive detection of Cr(VI) ion in water and neuroprotective effect on CO poisoning patients by reducing ROS production and oxidative stress

In the current study, by using the mixed ligand approach, a novel 2D metal–organic framework (MOF), [Zn(Hssa)(1,4-dtb)·H2O]n (H3ssa = 5-sulfosalicylic acid, dtb = 1,4-di(4H-1,2,4-triazol-4-yl)benzene) was synthesized with a high yield under solvothermal reaction conditions and through the elemental analysis and the single-crystal X-ray diffraction. Luminescence studies demonstrate that 1 is able to be utilized as a strongly sensitive luminescent sensor for Cr2O72− and CrO42− in H2O. Furthermore, the neuroprotective effect of the compound on CO poisoning patients was evaluated in biological research. The real-time RT-PCR was conducted to study the expression level of the ROS-related genes in the neurons. In addition to this, the activation of the superoxide dismutase (SOD) in the neurons was measured after treatment of the compound.