and antihyperglycemia effects of resvertrol and its derivative on alloxan diabetic rabbits

Background and objective:Resveratrol is a non flavonoid polyphenol ( Vitis vinifera) posses three phenolic hydroxyl group and shown to its biological effects. The derivations of resveratrol associated with the available oral hypoglycermic agents for treatment of diabetes mellutes type 2.. Materials and methods: The study has also employed an in vivo evaluation of resveratrol and its derivative in female rabbits at concentrations ( 1 mg / kg) given orally for 42 days after inducing diabetes mellitus type 2 by alloxan (100mg/1kg body weight). The serum was isolated from heart blood for the biochemical tests, including Glucose, Total protein Albumin and Insulin. At day 42 the animal was killed and the liver and pancreas were kept in 10% formalin for preparation of histopathological sections. Results: Statistical analysis showed a significant decrease in Glucose, total protein , Creatinine of serum blood levels on treated rabbits p > 0.05, However resveratrol and its derivative treated rabbits showed statistically significant increase in Insulin blood serum levels p > 0.05. Examination of the liver tissue confirmed potential histopathological effects for resveratrol , while derivative has normal appearance in a dose dependent manner. Examination of the pancreas tissue confirmed potential histopathological effects for resveratrol, and its derivatives has normal appearance in a dose dependent manner. The derivatives compound showed a significant differences than the other compounds extract regarding the serum activity of Insulin and hisopathological changes especially in pancreas.