EGFR mutations in Latinos from the United States and Latin America.

8070 Background: Activating mutations in the epidermal growth factor receptor gene (EGFR) confer hypersensitivity to EGFR tyrosine kinase inhibitors in patients with advanced non–small-cell lung cancer (NSCLC). Racial and ethnic differences in the frequency of such mutations have been previously described; however, there are limited and conflicting reports on its frequency in the Latino population. Methods: We collected samples from 642 patients with NSCLC from 7 institutions in the US and Latin-America. Activating EGFR mutation analysis of exons 18 through 21 was performed at 2 CLIA certified central laboratories. Statistical analyses were performed using Fisher’s exact test or Mehta’s modification to Fisher’s exact test to determine relationships among parameters. All p-values are two-tailed and reported without adjustment for multiple comparisons. Results: EGFR mutation analysis was successfully performed in 480 of 642 patients (75%) of which 90 (19%) were Latinos, 318 (66%) non-Latino Whites, 35 (7%) ...