Lipid accumulation product index: a reliable marker of cardiovascular risk in polycystic ovary syndrome
2009
results: LAP index was positively correlated with HOMA index in all subjects (r ¼ 0.70; P , 0.001). Waist circumference (WC) (P ¼ 0.002), HOMA index (P , 0.001) and LAP index (P ¼ 0.035) were higher in PCOS patients than controls. On receiver operating characteristic curve analysis, an LAP index of 34.5 (sensitivity: 84%; specificity 79%) showed a better performance than non-high-density lipoprotein cholesterol, WC or BMI to identify insulin resistance (IR) in all subjects. In PCOS patients, the positive and negative predictive values for LAP � 34.5 were 91 and 74%, respectively, compared with 73 and 61%, respectively, for WC � 80 cm, and 43 and 20%, respectively, for WC � 88 cm. conclusions: We have confirmed that IR is more common in PCOS than BMI-matched control women. Furthermore, the LAP index, an easily obtainable measure, is associated with HOMA index and an LAP � 34.5 is an additional risk factor for cardiovascular disease in PCOS patients.
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