Thermogenic effect of amrinone in healthy men

Design: A prospective, unblinded, controlled study. The initial control period was followed by three sequential, experimental treatments. Subjects: Ten young, healthy, male volunteers with normal body weight. Interventions: Three experimental periods. Amrinone was administered intravenously in progressive doses: a) 0.5 mg/kg followed by 5 μg/ kg/min; b) 0.5 mg/kg followed by 10 μg/kg/min; and c) 1.0 mg/kg followed by 10 μg/kg/min. Measurements and Main Results: Oxygen consumption (o2) and CO2 production were continuously measured by means of a computerized indirect calorimeter. At the highest dose, amrinone produced a slight and significant (p Conclusions: Amrinone administered intravenously at therapeutic doses has minimal thermogenic and metabolic effects in humans without cardiac failure. (Crit Care Med 1994; 22:1235–1240)