Chronic intermittent nicotine delivery via lung alveolar region-targeted aerosol technology produces circadian pharmacokinetics in rats resembling human smokers

Xuesi M. Shao,Siyu Liu,Eon S. Lee,David Fung,Hua Pei,Jing Liang,Ross Mudgway,Jingxi Zhang,Jack L. Feldman,Yifang Zhu,Stan G. Louie,Xinmin S. Xie

Chronic intermittent nicotine delivery via lung alveolar region-targeted aerosol technology produces circadian pharmacokinetics in rats resembling human smokers

2018

Xuesi M. Shao
Siyu Liu
Eon S. Lee
David Fung
Hua Pei
Jing Liang
Ross Mudgway
Jingxi Zhang
Jack L. Feldman
Yifang Zhu
Stan G. Louie
Xinmin S. Xie

We developed a lung alveolar region-targeted aerosol method and a system that provides chronic intermittent nicotine exposure in freely moving rodents. The method produces in rodents clinically rel...

Keywords:

Nicotine
Diabetes mellitus
NICOTINE EXPOSURE
Anesthesia
Circadian rhythm
Lung
Pharmacology
Chemistry
Pharmacokinetics
nicotine delivery

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