Statistical Methods in Drug Combination Studies

Preface Contributors Drug Combination: Much Promise and Many Hurdles Harry Yang and Laura Richman Drug Combination Synergy Harry Yang, Steven J. Novick, and Wei Zhao Drug Combination Design Strategies Steven J. Novick and John J. Peterson Confidence Interval for Interaction Index Maiying Kong and J. Jack Lee Two-Stage Response Surface Approaches to Modeling Drug Interaction Wei Zhao and Harry Yang A Bayesian Industry Approach to Phase I Combination Trials in Oncology Beat Neuenschwander, Alessandro Matano, Zhongwen Tang, Satrajit Roychoudhury, Simon Wandel, and Stuart Bailey Statistical Methodology for Evaluating Combination Therapy in Clinical Trials H.M. James Hung and Sue-Jane Wang Challenges and Opportunities in Analysis of Drug Combination Clinical Trial Data Yaning Wang, Hao Zhu, Liang Zhao, and Ping Ji Software and Tools to Analyze Drug Combination Data Cheng Su Appendix Index