Blockade of the Notch1/Jagged1 pathway in Kupffer cells aggravates ischemia-reperfusion injury of orthotopic liver transplantation in mice

He Bai,Jian Wen,Jianping Gong,Hao Wu,Fangchao Yuan,Ding Cao,Yakun Wu,Xing-lai,Menghao Wang

Blockade of the Notch1/Jagged1 pathway in Kupffer cells aggravates ischemia-reperfusion injury of orthotopic liver transplantation in mice

2019

He Bai
Jian Wen
Jianping Gong
Hao Wu
Fangchao Yuan
Ding Cao
Yakun Wu
Xing-lai
Menghao Wang

AbstractLiver ischemia-reperfusion injury (IRI) represents a risk factor for early graft dysfunction and an obstacle to expanding donor pool in orthotopic liver transplantation (OLT). Kupffer cells...

Keywords:

Immunology
Ischemia
Urology
Risk factor
Diabetes mellitus
Graft dysfunction
Blockade
Biology
Reperfusion injury
Liver transplantation
orthotopic liver transplantation
donor pool

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