Access to Fluorine‐Containing Asparagine and Glutamine Analogues via Palladium‐Catalyzed Formate Reduction

A synthesis of fluorine-containing asparagine and glutamine analogues via palladium-catalyzed formate reduction of fluorinated carbonate esters is described. Primary amide moieties at the side-chain of asparagine and glutamine were successfully replaced with fluoroolefins, which are proposed to be aprotic mimics for amides due to their electronic properties.