Monepantel resistant Trichostrongylus colubriformis in goats in Brazil

Abstract In a farm where Trichostrongylus colubriformis in sheep had been found resistant to monepantel (MNP), we aimed to evaluate the efficacy against gastrointestinal nematodes in a controlled efficacy test (CT) and a fecal egg count reduction test (FECRT) in goats. We used 15 (CT) and 30 goats (FECRT), naturally infected, and equally divided into control and treated groups. The efficacy of MNP in the CT against Haemonchus contortus , Trichostrongylus axei and Cooperia curticei was 100%. For T. colubriformis , the efficacy was 90.5% in goats treated with 2.5 mg/kg, and 88.1% in goats treated with 3.5 mg/kg. In the FECRT, the overall reduction was 91% (2.5 mg/kg) and 90% (3.75 mg/kg). In the fecal cultures, Trichostrongylus spp. larvae represented 25% (pre-treatment) and 15% (post-treatment) of the larvae in the control group, but they were 75% (2.5 mg/kg) and 98% (3.75 mg/kg) of the recovered larvae after MNP treatment. In accordance with published standards, and based on FECRT and CT, MNP was considered ineffective against T. colubriformis in the studied flock.