Hydrogen/Deuterium Isotopic Labeling Study of Enantioselective Hydrogenation of (E)-2-Methyl-2-butenoic Acid over a Cinchonidine-modified Pd/C Catalyst

In the enantioselecitve hydrogenation of (E)-2-methyl-2-butenoic acid (1) over a cinchonidine-modified Pd/C catalyst, the addition of hydrogen preferentially proceeds from the Re-Si enantioface of ...