Regio- and stereoselective synthesis of Z-vinylic tellurides from propargylic alcohols: a route to chiral Z-enynes

Abstract tert -Butyldimethylsilyl ethers of propargylic alcohols are hydrotellurated regioselectively to give 1,2- Z -vinylic tellurides. Enantiomerically pure propargylic alcohols give enantiomerically pure vinylic tellurides, which are coupled with alkynes under Pd catalysis to give enantiomerically pure allylic enynols.