Modification of Brain Ischemia Due to Embolic Stroke by Tissue-Type Plasminogen Activator With and Without Heparin in a Rabbit Model

This communication presents the results of an assessment of the ability of tissue-type plasminogen activator (t-PA), with and without heparinization, to modify the volume of ischemic brain tissue resulting from the introduction into the anterior cerebral circulation of the rabbit model of an embolus of standard size composed of white thrombus [5].