DETRIMENTAL EFFECTS OF FLUVASTATIN ON PLASMA LIPID METABOLISM IN RAT BREAST CARCINOMA MODEL
2013
From clinical practice, obvious positive effects of statins on plasma lipid
metabolism are well known. On the other hand, there are several experimental
rodent studies, where these beneficial effects were not confirmed. The
effects of fluvastatin on selected serum lipid parameters in a rat model of
experimental breast cancer were determined. The drug was dietary administered
at two concentrations of 20 and 200 mg/kg. At the end of the study
(experiment duration - 18 weeks) the blood from each animal was collected and
serum lipid parameters were evaluated. Fluvastatin in both treated groups
significantly increased parameters of serum lipids (mostly in a dose
dependent manner). Fluvastatin in both treated groups of animals
significantly increased serum levels of triacylglycerols, total cholesterol,
and LDL-, HDL-, VLDL-cholesterol when compared to the control group. Our
results pointed out to the apparent harmful effects of fluvastatin on plasma
lipid metabolism in rat mammary carcinogenesis. Based on our previous
results, it seems that rats commonly used in cancer model studies are
generally unresponsive to the hypocholesterolemic effects of statins.
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