Pharmacokinetics and Urinary Excretion of Cefpirome Following Single Intravenous Administration in Cross Bred Calves

Pharmacokinetics and urinary excretion of cefpirome (10 mg/kg, iv) were performed in five male cross-bred calves (Holstein Friesian X Sahiwal). Cefpirome was detected in plasma up to 14 h and rapidly distributed from blood to peripheral compartment as evidenced by high values of α and K12. Vdarea of 0.55 ± 0.02 l/kg revealed moderate drug distribution. Short elimination half-life and high body clearance indicated rapid elimination of the drug, while 62.6 % of administered dose of cefpirome was eliminated in urine within 24 h. The study suggests that a dose of 10 mg/kg, iv at 12 h interval would be effective against bacterial pathogens with MIC values ≤1.0 μg/ml. Key words: cefpirome, calves, pharmacokinetics, urinary excretion