Change and Significance of Serum Endothelin,Parathormone and Calcium in Neonatal Hypoxic Ischemic Encephalopathy

Objective: To study the change of ser um endothelin (ET), parathormone (PTH) and calcium in newborns with hypoxic ischemic encephalopathy (HIE). Method s: In a total of 42 newborns with mild, moderate and severe HIE were measu red ser um concentration of calcium and that of ET, PTH using RIA technique in 72 hours after they born. The ET, PTH and calcium values of 30 healthy newborns as control group were also measured. Results: ET levels were higher and calcium levels were lower significantly in each group of HIE than that of controls. And significant differences were observed between the mild and moderate HIE group,the moderate and severe HIE groups. PTH levels were signi ficantly reduced in the moderate and severe HIE newborns compared with the mild and control groups. There was no statistical difference between the mild HIE g roup and control group, the moderate and severe HIE groups. Conclusions: ET levels increase and calcium levels reduce in the newborns with HIE, va riation depends on severity of the disease. The serum concentration of PTH r e duces in the moderate and severe newborns with HIE. This is a secondary marker t o evaluate the situation and therapy of newborns with HIE.