Fusion to Human Serum Albumin Extends the Circulatory Half-Life and Duration of Antithrombotic Action of the Kunitz Protease Inhibitor Domain of Protease Nexin 2

William P. Sheffield,Louise J. Eltringham-Smith,Varsha Bhakta

Fusion to Human Serum Albumin Extends the Circulatory Half-Life and Duration of Antithrombotic Action of the Kunitz Protease Inhibitor Domain of Protease Nexin 2

2018

William P. Sheffield
Louise J. Eltringham-Smith
Varsha Bhakta

Background/Aims: The Kunitz Protease Inhibitor (KPI) domain of protease nexin 2 (PN2) potently inhibits coagulation factor XIa. Recombinant KPI has been shown to

Keywords:

Protease
Antithrombotic
Protease Nexin
Biochemistry
Human serum albumin
Half-life
Recombinant KPI
Circulatory system
Pharmacology
Albumin
Biology
Fusion protein
In vivo
Pichia pastoris
Low-density lipoprotein

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