Aspartate-β-hydroxylase (ASPH): A potential therapeutic target in human malignant gliomas
2016
Background
Despite therapeutic advances, survival with glioblastoma multiforme (GBM) remains below 15 months from diagnosis due to GBM’s highly infiltrative nature which precludes complete surgical resection. Patient outcomes could potentially be improved by targeting genes and pathways that drive neoplastic cell motility and invasiveness, including hypoxia-inducible factor-1 (HIF-1α), NOTCH, and aspartate-β-hydroxylase (ASPH).
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
37
References
16
Citations
NaN
KQI