Treating Acne with Octadecenedioic Acid: Mechanism of Action, Skin Delivery, and Clinical Results
2007
Acne is and will always remain a disturbing disease because it is highly visible as
well as manifesting itself at an age when young teenagers are very concerned about
their looks. However, to state that acne is only limited to adolescents (where males
tend to show the more severe forms of the disease) is wrong, as especially postadolescent women are also affected by the disease (1). The primary cause of acne is
an obstruction of the pilosebaceous canal. This is due to at least four pathogenic
factors: (i) increased proliferation, cornification, and shedding of follicular epithelium (i.e., hyperkeratinization); (ii) increased sebum production (i.e., hyperseborrhea); (iii) colonization of the follicle with Propionibacterium acnes and
Staphylococcus aureus (i.e., microbes); (iv) induction of inflammatory responses by
bacterial antigens and cell signals (i.e., inflammation) (2). Earlier chapters of this
book will have dealt extensively with these etiological and pathogenetical aspects
of acne.
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