Asperpyrone D and other metabolites of the plant-associated fungal strain Aspergillus tubingensis

Abstract Bioactivity-guided fractionation of a cytotoxic extract of Aspergillus tubingensis , a fungal strain occurring in the rhizosphere of the Sonoran desert plant, Fallugia paradoxa , afforded a dimeric naphtho-γ-pyrone asperpyrone D, nine known naphtho-γ-pyrones, funalenone, and the cytotoxic cyclic penta-peptide, malformin A 1 .