Hepatobiliary jaundice in children:pathogenesis and relative diseases
2009
Hepatobiliary jaundice in children was caused by diseases which damage liver cells and/or biliary system. Unconjugated bilirubin in serum can not be fully transformed into conjugated bilirubin inside the hepatocytes, and/or all conjugated bilirubin can not be drained with bile through biliary system and finally go into intestine. So both serum unconjugated and conjugated bilirubin were elevated and lead to jaundice. Hepatobiliary jaundice can be divided into subcellular jaundice, hepatocellular jaundice, cholangio-jaundice, and mixture. Except Crigler-Najjar syndrome, no significant injury would be induced either by unconjugated bilirubin or conjugated bilirun. Therefore, the most important thing is to find out the underlying diseases and treat them accordingly.
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