Triplex Formation Using Oligonucleotide Clamps Carrying 8-Aminopurines

Anna Aviñó,Marta G. Grimau,Margarita Alvira,Ramon Eritja,Raimundo Gargallo,Modesto Orozco,Carlos González

Triplex Formation Using Oligonucleotide Clamps Carrying 8-Aminopurines

2007

Anna Aviñó
Marta G. Grimau
Margarita Alvira
Ramon Eritja
Raimundo Gargallo
Modesto Orozco
Carlos González

The synthesis and properties of triplex-forming DNA clamps carrying 8-aminopurines are described. The stability of triple helices is enhanced by replacing purine bases with 8-aminopurine residues. These enhanced binding properties are used for the specific capture of polypyrimidine RNA/DNA sequences of interest.

Keywords:

HMG-box
DNA sequencing
Oligonucleotide
Purine
Biochemistry
DNA
RNA
Triple helix
Chemistry
Molecular biology
Molecular probe

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