Advances of molecular mechanisms of oxidative stress in obstructive sleep apnea syndrome and stroke

Obstructive sleep apnea (OSA) is a high incidence of potentially dangerous disease, characterized by intermittent hypoxia or hypercapnia.It is an independent risk factor for ischemic stroke.Currently a number of studies have confirmed OSA closely associated with oxidative stress.In this paper, the complex mechanisms of oxidative stress in the OSA and the occurrence of stroke will be reviewed, such as promoting atherosclerosis, damaging the mitochondria, ischemia-reperfusion injury, ischemic preconditioning.To investigate the relationship between OSA, oxidative stress and stroke from molecular mechanisms. Key words: Sleep apnea, obstructive; Oxidative stress; Stroke