Liposome-encapsulated recombinant human ciliary neurotrophic factor

The invention provides a liposome-encapsulated recombinant human ciliary neurotrophic factor (rhCNTF) containing monosialo ganglioside (GM1) and a preparation method thereof. Particle diameters of liposome of the rhCNTF prepared by adopting the preparation method is evenly distributed within a range of 20 to 200nm, and the drug encapsulating rate is no less than 70 percent. An animal experiment proves that by adopting the rhCNTF liposome, the rhCNTF can pass through a blood brain barrier, and the rhCNTF liposome has the application value of curing diseases related to neuronal damages and degenerative diseases.