The optimal level of serum vitamin D in apparently healthy Bangladeshi adult volunteer

Introduction: Vitamin D level has profound clinical implications but there is a dilemma of optimal vitamin D cut off level among the Bangladeshi population as well in many parts of the world. This study aimed to determine the optimal level of vitamin D in relation to intact parathyroid hormone (iPTH) and serum calcium in apparently healthy adult volunteer. Methods: This observational cross-sectional study was carried out in 130 apparently healthy adult participants of BSMMU. All the subjects were taken their demographic profile and investigated for vitamin D level, iPTH, corrected calcium and phosphate. Serum 25(OH)D was measured by high-performance liquid chromatography (HPLC) whereas iPTH, corrected serum calcium and serum phosphate were measured by chemiluminescent method. Results: The mean 25(OH)D level was found to be 16.78(SD8.47) ng/ml and extensively distinct by age distribution and adequacy of sun exposure. There was substantially inverse correlation between serum iPTH and serum 25(OH)D (r = - 0.22, p = 0.01). Serum 25(OH)D levels < 27.5ng/ml were associated with a steep increase in serum iPTH levels. Serum iPTH was stabilized at level 54.5pg/ml by using the quadratic fit with plateau model. Conclusions: From this study the optimal level of 25(OH)D for the apparently healthy adult in Bangladesh is 27.5 ng/ml.