Genetic differences of prostate cancer between Eastern and Western population

Morbidity and mortality of prostate cancer vary widely between Eastern and Western population,which is mainly due to genetic factors.In order to further explore the different mechanisms of occurrence and development of prostate cancer,the prostate cancer susceptibility genes,such as RNASEL,ELAC2,PTEN,MSR1 and TMPRSS2-ERG are selected,and the genotype and allele distribution differences among Hispanic whites,African American,European,Chinese and Japanese are compared. Key words: Prostate neoplasms;  Genetic predisposition to disease;  Gene fusion