Isoxazoline derivatives as potential inhibitors of the proteolytic enzymes human leukocyte elastase, cathepsin G and proteinase 3: a structure-activity relationship study.

William C. Groutas,Radhika Venkataraman,Lee S. Chong,James E. Yoder,Jeffrey B. Epp,Michael A. Stanga,Eun-Hong Kim

Isoxazoline derivatives as potential inhibitors of the proteolytic enzymes human leukocyte elastase, cathepsin G and proteinase 3: a structure-activity relationship study.

1995

William C. Groutas
Radhika Venkataraman
Lee S. Chong
James E. Yoder
Jeffrey B. Epp
Michael A. Stanga
Eun-Hong Kim

Abstract A series of isoxazoline derivatives were synthesized and investigated for their in vitro inhibitory activity towards human leukocyte elastase, cathepsin G and proteinase 3.

Keywords:

Cathepsin O
Enzyme
Cathepsin L1
Proteinase 3
Cathepsin A
Structure–activity relationship
Biochemistry
Chemistry
Cathepsin G
In vitro
proteolytic enzymes

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