Posaconazole for the Prophylaxis and Treatment of Invasive Aspergillosis: A Review of Clinical Effectiveness and Guidelines

The purpose of this report is to review provide a synthesis of the best available evidence on the clinical effectiveness of posaconazole for the treatment and prophylaxis of invasive aspergillosis (IA) and to review and summarize recommendations from the related evidence-based guidelines. This report is an update of a previous CADTH Rapid Response report (2016), which found favourable evidence regarding the use of posaconazole for the treatment and prophylaxis of aspergillosis and candidiasis. However, the present review is exclusively focused on aspergillosis.