Role of ACE Inhibition in IgA Nephropathy

In ten patients with IgA nephropathy, GFR, RPF, FF, renal vascular resistance, FeNa and proteinuria were evaluated, baseline and after 16 weeks of Enalapril therapy. GFR did not change, RPF and FeNa increased, RVR and FF decreased. Daily urinary protein excretion reduced in five but two of 7 proteinuric pts. Enalapril may be effective in preventing the glomerular capillary hypertension and the development of the glomerular sclerotic lesions.