New aspects regarding the cosmetic outcome after neoadjuvant radiochemotherapy in breast cancer patients.

e11505 Background: Neoadjuvant radiochemotherapy (NRT-CHX) is an innovative technique for the treatment of patients with locally advanced non inflammatory breast cancer (LABC). The aim of this study was to analyze the long term cosmetic outcome in breast conserving and mastectomy patients after NRT-CHX. Methods: In a time period from 1991 to 1998 a total of 315 LABC patients (cT1-cT4/cN0-N1) were treated with NRT-CHX. 160 patients received a breast conserving surgery (BCS) and 154 patients were treated with mastectomy (ME). One patient had no surgery.Preoperative radiotherapy (RT) consisted of external beam radiation therapy (EBRT) of 50 Gy (5 × 2 Gy/week) to the breast and the supra-/infraclavicular lymph nodes (255 patients) combined with a consecutive electron boost in 214 cases or - a 10-Gy interstitial boost with (192)Ir afterloading before EBRT in 101 of the patients' cases. Chemotherapy with CMF and AC/EC was administered prior to RT in 192 patients, and Mitoxantrone concomitantly in n=113 patients...