Models of cranial suture biology.

Craniosynostosis is a common congenital defect caused by premature fusion of cranial sutures. The severe morphological abnormalities and cognitive deficits resulting from craniosynostosis and the potential morbidity of surgical correction espouse the need for a deeper understanding of the complex etiology for this condition. Work in animal models over the past twenty years has been pivotal in advancing our understanding of normal suture biology and elucidating pathological disease mechanisms. This article provides an overview of milestone studies in suture development, embryonic origins, and signaling mechanisms from an array of animal models including transgenic mice, rats, rabbits, fetal sheep, zebrafish, and frogs. This work contributes to an ongoing effort toward continued development of novel treatment strategies.