Combined Role of Two Tryptophane Residues of α-Factor Pheromone

]α-factoramide ( 10) were found to have antagonistic activity. Analogs 3 and 6 showed greater antagonistic activity thananalogs 8 and 10. Key Words : α-Factor, Amide analogs, S. cerevisiae, ActivityIntroductionThe α-factor, tridecapeptide (WHWLQLKPGQPMY), issecreted by Saccharomyces cerevisiae MATa haploid cellsand recognized by a receptor that is coded by gene (STE2)which is expressed in S. cerevisiae MATa haploid cells.