Socio-economic Burden of Bloodstream Infections Caused by Carbapenem-resistant and Carbapenem susceptible Pseudomonas aeruginosa in China.

Background Drug resistance in Pseudomonas aeruginosa is a serious threat to patient safety. In addition to this clinical impact, it is important to understand the associated socio-economic burden, but there are few such studies. Methods Clinical information and hospital cost data for patients in a tertiary teaching hospital from 2011 to 2016 with P. aeruginosa bloodstream infections (BSIs) were collected retrospectively to estimate the direct economic burden. The socio-economic loss incurred by patients was calculated using the human capital approach combined with estimating Disability Adjusted Life Years (DALYs). The differences in socio-economic burdens between BSIs caused by carbapenem-resistant P. aeruginosa (CR-PAE) and carbapenem susceptible P. aeruginosa (CS-PAE) were compared. Results Data for 220 patients were included in this study, of which CR-PAE BSIs accounted for 29.5% (65/220). The median direct economic burden of patients after a CR-PAE BSI was significantly higher than those with a CS-PAE BSI ($5005.94 vs $1462.86, p Conclusion The economic burden of P. aeruginosa BSIs is significant, irrespective of carbapenem resistance. The direct economic burden of CR-PAE BSI was at least threefold that of CS-PAE BSI.The DALY loss caused by CR-PAE BSI is threefold that caused by CS-PAE BSI.The indirect socio-economic loss caused by CR-PAE BSI is more than twice that caused by CS-PAE BSI.