65. Cortical sources of resting state EEG rhythms reflect disease progression over 1 year in mild cognitive impairment and Alzheimer’s disease patients

Cortical sources of resting state electroencephalographic (EEG) rhythms are abnormal in subjects with mild cognitive impairment (MCI) and in patients with Alzheimer’s disease (AD). Here, we tested the hypothesis that they reflect disease progression for future clinical trials. Resting state eyes-closed EEG data were recorded in 54 amnesic MCI subjects and in 88 mild AD patients at baseline and at 1-year follow up. LORETA was used for data analysis. In the mild AD patients, the follow-up EEG recordings showed increased power of widespread delta sources as well as decreased power of widespread alpha and posterior beta 1 sources ( p p Cortical sources of resting state EEG rhythms may be used as secondary “surrogate” end points for drug discovery in prodromal and manifest AD patients.