Amino acid adducts of PAH o-quinones: model studies with naphthalene-1,2-dione
2001
Abstract Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants which may cause cancer and require metabolic activation to exert their carcinogenic effects. As a step toward identifying the spectrum of PAH o -quinone-amino acid adducts that may form in biological systems, several naphthalene-1,2-dione-amino acid adducts were synthesized. Each adduct was formed as a 1,4-Michael addition product and spectral data corroborate that these adducts were either o -quinones or catechols. PAH o -quinone adducts can be used as standards to identify their presence in vitro and in vivo.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
25
References
5
Citations
NaN
KQI