Effects of Smoking on Rat Peptic Ulcer

SD rats weighing 200 ± 10g were used, 12 of 40 rats were randomly selected as those in sham group, and the remaining 28 were used to establish the acetic acid-induced gastric ulcers to observe effects of smoking on the rat gastric ulcer and ulcer area. The acetic acid-induced gastric ulcer model in rats is reliable. Smoking can delay or the healing of ulcer, which may be related to the increase of gastric acid secretion induced by smoking, the increase in oxygen free radicals that can damage the mucosa of stomach, the decrease of pyloric sphincter tension, the reflux of bile and duodenal fluid to the stomach, and the reduction of prostaglandin E content in mucosa. It is recommended that in the treatment process of patients with gastric ulcer, they should stay away from smoking places, as much as possible avoid the hazards of passive smoking.