Pioglitazone Regulation of Glucose in a High-Salt-Fed db/db mice. (LB553)

Estimates from the World Health Organization indicate that there are some 347 million people diagnosed with diabetes worldwide. Diabetes mellitus is a metabolic disorder characterized by hyperglycemia, and associated with abnormalities in carbohydrate, fat and protein metabolism. Complications of diabetes include microvascular, macrovascular, and neuropathic problems. A recent study showed that more than 30% of people recently diagnosed with type 2 Diabetes had hypertension. Diabetes is also the leading cause of end-stage-renal disease which manifests as disturbances in the ability of the kidneys to handle sodium. The thiazolidinediones (TZDs) e.g. pioglitazone introduced for the treatment of type 2 Diabetes are ligands for peroxisome proliferator activated gamma receptors (PPAR gamma). They reduce glucose level by reducing insulin resistance. The objective of this study was to evaluate the impact of high-salt-diet on pioglitazone treated db/db mice. Groups of 6 weeks-old db/db mice obtained from Jackson ...