The Effectiveness of Adjunctive Systemic Antibiotics to Non Surgical Therapy in Chronic Periodontitis Patients

Background: The aim of this study was to assess the clinical and microbiological effects of moxifloxacin (MOX) and combined amoxicillin and metronidazole (AMX+ MET) as an adjunct to scaling and root planning (SRP) and to compare it to conventional mechanical periodont al treatment alone in patients with advanced chronic periodontitis by means of a species - specific sequences of DNA. Methods: Clinical parameters and subgingival bacterial plaque sample were collected from forty two subjects divided into three groups. Scali ng and root planning (SRP) group, SRP with amoxicillin plus metronidazole and third group SRP with moxifloxacin. Data obtained before initial therapy, at 3 and 6 months after completion of therapy for evaluation of four different periodontopathogenic speci es using the quantitative PCR technique. Results: The results of the present study revealed that the three treatment modalities resulted in significant reduction in PI, GI, PD, and the CAL over time although there was n o significant difference between grou ps at different follow up periods . There was statistically significant strong positive correlation between clinical parameters and bacterial count. Conclusion: This study confirms the efficiency of non surgical periodontal treatment to achieve reduction of the periodontal pockets and to ensure proper conditions for effective plaque control and stable levels of the periodontal attachment. Antibiotic prescribing should be the exception rather than the rule and only considered after conventional therapies have been unsuccessful. ( Riham Omar Ibrahim and Olfat Shaker . The Effectiveness of Adjunctive Systemic Antibiotics to Non Surgical Therapy in Chronic Periodontitis Patients . J Am Sci 2012;8(12): 374 - 383 ). (ISSN: 1545 - 1003). http://www.jofamericanscience.org . 52