MULTIPURPOSE MICROCHIP SYSTEM FOR PHOTOMETRIC CHEMICAL ANALYSIS INTEGRATED WITH TEMPERATURE CONTROLLED SOLUTION MIXER

In this paper, practical useable microchip for chem ical analysis is presented. The microchip can be performing photometric detection of solution, i.e. absorptiometry and turbidimetry, using integrated high performance long optical path length sensor. Moreover, high uniformity solution mixer is integrated as pre-treatment unit. Sample solution is not only mixed with reagent, but also controlled temperature by integrated micro-heater and feedback control circuit. Thanks to high performance mixer and temperature control mechanism, chemical reaction speed becomes constant, reproducibility and accuracy of measurement becomes higher. As one of demonstration of practical use for blood testing, C-reactive protein (CRP) was measured using the microchip by Latex Turbidimetric Immunity Assay (LTIA) method.