MP01-13 ANTI-PPP1CA AUTOANTIBODY DETECTED BY PROTEOMICS ANALYSES IS ASSOCIATED WITH BIOLOGICAL AGGRESSIVENESS AND POOR PROGNOSIS IN PATIENTS WITH BLADDER CANCER

malignancy, chronic indwelling catheter, and glomerular disease were excluded. The risk factors specified by the current AUA MH guidelines include smoking history, irritative voiding symptoms, chemotherapy exposure, and pelvic irradiation. Univariate and multivariate logistic regression analyses were performed to explore the association between these risk factors and the presence of genitourinary malignancy. Covariates analyzed included age, gender, number of RBC/HPF ( 50 years was associated with malignancy on univariate, but not multivariate analysis. Chemotherapy exposure, pelvic irradiation and number of RBC on urinalysis were not predictive of malignancy. CONCLUSIONS: MH can serve as an early indicator of urologic malignancy, however, its presence may not always warrant a comprehensive work-up. Male gender, positive smoking history, and irritative voiding symptoms were identified as risk-factors independently predictive of malignancy and thus, their presence justifies a thorough evaluation. In patients without these risk factors, the universal application of CT urography should be judiciously considered.