Analytical method development & validation of Eperisone Hydrochloride and Diclofenac Sodium in Rapisone D SR Capsules
2013
Acetonitrile in the ratio of 30:40:30 (v/v/v) pumped at a flow-rate of 1.0 mL/min. The PDA detector was employed at a wavelength of 261nm. The retention times of Diclofenac Sodium & Eperisone Hydrochloride were found to be 2.21 min and 3.6 min respectively. The calibration curves were linear in the range of 2080µg/mL & 30-120 µg/mL for DIC & EPE. The method is accurate with %w/w recoveries of 99.03% & 100.9 % for Diclofenac Sodium and Eperisone Hydrochloride respectively & the method is precise with % RSD < 2.The proposed method is rapid, simple and does not require any separation process and it has been successfully applied to the assay of pharmaceutical dosage form( RAPISONE D SR capsules ).
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