Voruciclib, a Potent CDK4/6 Inhibitor, Antagonizes ABCB1 and ABCG2-Mediated Multi-Drug Resistance in Cancer Cells

Pranav Gupta,Yun-Kai Zhang,Xiao-Yu Zhang,Yi-Jun Wang,Kimberly W. Lu,Timothy Hall,Richard Peng,Dong-Hua Yang,Ni Xie,Zhe-Sheng Chen

Voruciclib, a Potent CDK4/6 Inhibitor, Antagonizes ABCB1 and ABCG2-Mediated Multi-Drug Resistance in Cancer Cells

2018

Pranav Gupta
Yun-Kai Zhang
Xiao-Yu Zhang
Yi-Jun Wang
Kimberly W. Lu
Timothy Hall
Richard Peng
Dong-Hua Yang
Ni Xie
Zhe-Sheng Chen

Background/Aims: The overexpression of ATP-Binding Cassette (ABC) transporters has known to be one of the major obstacles impeding the success of chemotherapy in

Keywords:

Drug resistance
Cancer cell
Abcg2
Biochemistry
Cancer research
Multiple drug resistance
Chemotherapy
Biology
Apoptosis
Paclitaxel
Imino Furanoses

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