Maternal derivative chromosome 9 and recurrent pregnancy loss

Objective To disclose the relationship between a derivative chromosome 9 and recurrent pregnancy loss. Design Case report. Setting Referral from primary clinical care to tertiary hospital for further intervention. Patient(s) A 31-year-old woman who had four recurrent early spontaneous abortions. Intervention(s) Cytogenetic and fluorescence in situ hybridization analyses of the chromosome harvested from peripheral blood sample. Main Outcome Measure(s) Karyotype of the patient. Result(s) The patient has a unique derivative chromosome 9, der(9)(9qter→9p24::9p24→9p11::9p13→9qter). ish der(9) (CEP9×1,43N6×1,D9Z3×1). Conclusion(s) Maternal derivative chromosome 9 may cause recurrent pregnancy loss.