Study on the Primary Culture and Chemotherapeutic Drug Sensitivity of Breast Cancer Cells

Objective: To investigate the chemosensititivity of three vinds chemotherapeutic drug groups on different the histologic types,age and lymph node metastasis status of breast carcinoma by the primary culture of breast cancer cell.Methods: Fresh samples from 109 patients with breast cancer were obtained during operation.The breast cancer cells were cultured in primary to test the 3 groups drugs sensitivity by MTT method.Results:The sensitivity rates of the breast cancer were(from high to low) CAF(33.0%),TA(31.2%) and CMF(26.6%).There was no significant difference in sensitivity(P0.05) among the age groups,the histologic type groups and the lymph node metastasis groups.Conclusion:To choose chemotherapeutic drugs by MTT assay has important significance in treating breast cancer.The breast cancer cells are sensitive to CAF,TA and CMF,but no significance.