Combination of a pde4 and tiotrope inhibitor or a derivative of the same to treat obstructive respiratory roads and other inflammatory diseases.

A combination of therapeutic agents useful for the treatment of obstructive airways and other inflammatory diseases containing (I) a PDE4 inhibitor that is therapeutically effective for the treatment of such diseases when administered by inhalation; together with (II) an anticholinergic agent consisting of a component chosen from the group consisting of tiotropium and derivatives thereof, which is therapeutically effective for the treatment of said diseases when administered by inhalation, said PDE4 inhibitor consists of a chosen component among the group consisting of the following: 9-cyclopentyl-5, 6-dihydro-7-ethyl-3-phenyl-9H-pyrazolo [3, 4-c] -1, 2, 4-triazolo [4, 3-a ] pyridine; 9-cyclopentyl-5, 6-dihydro-7-ethyl-3- (furan-2-yl) -9H-pyrazolo [3, 4-c] -1, 2, 4-triazolo [4, 3-a] pyridine ; 9-cyclopentyl-5, 6-dihydro-7-ethyl-3- (2-pyridyl) -9H-pyrazolo [3, 4-c] -1, 2, 4-triazolo [4, 3-a] pyridine; 9-cyclopentyl-5, 6-dihydro-7-ethyl-3- (4-pyridyl) -9H-pyrazolo [3,4-c] -1,2,4-triazolo [4,3-a] pyridine; 9-cyclopentyl-5, 6-dihydro-7-ethyl-3- (3-thienyl) -9H-pyrazolo [3, 4-c] -1, 2, 4-triazolo [4, 3-a] pyridine; 3-benzyl-9-cyclopentyl-5, 6-dihydro-7-ethyl-9H-pyrazolo [3, 4-c] -1, 2, 4-triazolo [4, 3-a] pyridine; 9-cyclopentyl-5, 6-dihydro-7-ethyl-3-propyl-9H-pyrazolo [3, 4-c] -1, 2, 4-triazolo [4, 3-a] pyridine; 3, 9-dicyclopentyl-5, 6-dihydro-7-ethyl-9H-pyrazolo [3, 4-c] -1, 2, 4-triazolo [4, 3-a] pyridine; 9-cyclopentyl-5, 6-dihydro-7-ethyl-3- (1-methylcyclohex-1-yl) -9H-pyrazolo [3, 4c]] - 1, 2, 4-triazolo [4, 3-a] pyridine; 3- (tert-butyl) -9-cyclopentyl-5, 6-dihydro-7-ethyl-9H-pyrazolo [3, 4-c] -1, 2, 4-triazolo [4, 3-a] pyridine; 9-cyclopentyl-5, 6-dihydro-7-ethyl-3- (2-methylphenyl) -9H-pyrazolo [3, 4-c] -1, 2, 4-triazolo [4, 3-a] pyridine; 9-cyclopentyl-5, 6-dihydro-7-ethyl-3- (2-methoxyphenyl) -9H-pyrazolo [3, 4-c] -1, 2, 4-triazolo [4, 3-a] pyridine; 9-cyclopentyl-5, 6-dihydro-7-ethyl-3- (tien-2-yl) -9H-pyrazolo [3, 4-c] -1, 2, 4-triazolo [4, 3-a] pyridine ; 3- (2-Chlorophenyl) -9-cyclopentyl-5, 6-dihydro-7-ethyl-9H-pyrazolo [3, 4-c] -1, 2, 4-triazolo [4, 3-a] pyridine; 9-cyclopentyl-5, 6-dihydro-7-ethyl-3- (2-iodophenyl) -9H-pyrazolo [3, 4-c] -1, 2, 4-triazolo [4, 3-a] pyridine; 9-cyclopentyl-5, 6-dihydro-7-ethyl-3- (2-trifluoromethylphenyl) -9H-pyrazolo [3, 4-c] -1, 2, 4-triazolo [4, 3-a] pyridine; and 5, 6-dihydro-7-ethyl-9- (4-fluorophenyl) -3- (1-methylcyclohex-1-yl) -9H-pyrazolo [3, 4-c] -1, 2, 4-triazolo [ 4, 3-a] pyridine.