Prevention of hereditary carcinogenesis

Cancer is a heritable disorder of somatic cells. The environment and heredity both operate in the origin of human cancer. Hereditary cancers in animals provide valuable experimental models for understanding the mechanisms of disease, and the development of the therapeutic treatments which can be translated into human patients, as well as how environmental factors interact with cancer susceptibility genes. Here, we show the example for cancer prevention in Tsc2 gene mutant hereditary renal carcinogenesis by introducing IFN-y transgene.