Research of the Influence of the LIG4 Gene Polymorphism on the Chromosomal Aberration Level in Human Lymphocytes, with Background And Excessive Exposure to a Radon

The effects of LIG4 gene polymorphisms rs1805388 (Thr9lle) and rs1805389 (Ala3Val) on the level of chromosomal aberrations in the lymphocytes of peripheral blood was estimated for children that live and study in conditions of normal and supernormal radon exposure in several locations in Kemerovskaya oblast. A statistically significant difference of the cytogenetic values among genotypic groups with the use of marker rs1805388 was not shown. At the same time, in the group of Val carriers (marker rs1805389) from the second cohort of our analysis revealed a significant increase of the amount of paired fragments in comparison to homozygotes Ala/Ala.