Effect of nicotinic acid on phosphodiesterase and adenyl cyclase activities in chicken liver

: Stimulation of fatty acid biosynthesis by feeding high-carbohydrate diet to chickens after fasting induces a 38% and 23% rise in the 3':5'-cyclo-nucleotide phosphodiesterase and adenylate cyclase activities in the liver tissue, respectively. Administration of nicotinic acid (150 mg per 1 kg of weight) to chickens with stimulated biosynthesis of fatty acids leads to a sharp (70% at an average) decrease of 3':5'-cyclo-nucleotide phosphodiesterase activity, the adenylate cyclase activity under these conditions remains practically unchanged. The participation of the adenylate cyclase system in regulating the fatty acid biosynthesis under mentioned conditions, the role of phosphodiesterase are discussed.