Long-term treatment outcomes of 831 patients with primary hepatic carcinoma who received personalized integrated surgical therapy in a single-institution

Objective To investigate the long-term outcomes of patients with primary hepatic carcinoma (PHC) who received personalized integrated surgical therapy.Methods The clinical data of 831 patients with PHC treated at the General Surgery Department of the Capital Medical University Affiliated Beijing Youan Hospital between March 2004 and September 2013 were retrospectively analyzed.The patients were grouped according to tumor staging,pathology and type of operation.The overall survival and tumor free survival rates were calculated and the survival rates in the different groups were compared.Results Of the 796 patients with PHC who received regular follow-up,the 1-,3-,5-year overall survival and tumor free survival rates were 88.6％,71.7％,61.3％ and 69.6％,47.9％,38.4％ respectively.For the 742 patients with hepatocellular carcinoma,the 1-,3-,5-year overall survival and tumor free survival rates were 89.6％,73.2％,63.2％ and 72.1％,52.5％,45.5％ respectively.The liver transplantation (LT) group and the liver resection group had better survival than the radio frequency ablation (RFA) group.The LT group had significantly better survival after 60 months of surgery than the liver resection group.Conclusion The personalized integrated surgical therapeutic model improved the therapeutic efficacy. Key words: Primary hepatic carcinoma;  Personalized integrated therapeutic model;  Long-term therapeutic effect